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Corresponding author. Received Aug 4; Accepted Nov Abstract The objective of this study was to compare a novel controlled release tablet formulation based on interpolyelectrolyte complex PEC. The formation of inter-macromolecular ionic bonds between cationic polymer and anionic polymer was investigated using Fourier transform infrared FT-IR spectroscopy and differential scanning calorimetry. The FT-IR spectra of the tested polymeric matrices are characterized by visible changes in the observed IR region indicating the interaction between chains of two oppositely charged copolymers.

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Corresponding author. Received Aug 4; Accepted Nov Abstract The objective of this study was to compare a novel controlled release tablet formulation based on interpolyelectrolyte complex PEC. The formation of inter-macromolecular ionic bonds between cationic polymer and anionic polymer was investigated using Fourier transform infrared FT-IR spectroscopy and differential scanning calorimetry. The FT-IR spectra of the tested polymeric matrices are characterized by visible changes in the observed IR region indicating the interaction between chains of two oppositely charged copolymers.

The performance of the in situ formed PEC as a matrix for controlled release of drugs was evaluated, using acetaminophen as a model drug. The dissolution data of these matrices were fitted to different dissolution models. It was found that drug release followed zero-order kinetics and was controlled by the superposition of the diffusion and erosion.

These profiles could be controlled by conveniently modifying the proportion of the polymer ratio, polymer type, and polymer concentration the in the tablets. Various types of oppositely charged polyelectrolytes interact electrostatically in aqueous media to form an insoluble solid or PEC 2 — 5. Polymethacrylate polymers have been widely used in pharmaceutical formulations as film-coating agent and as matrix carriers in solid dispersion preparation and in hot-melt extrusion processes 13 — The ratio of dimethylaminoethyl methacrylate groups to butyl methacrylate and methyl methacrylate groups is about The ratio of free carboxyl groups to the ester groups is approximately The carboxylic groups ionize in aqueous media at pH 5.

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Hiranandani College of Pharmacy, Smt. CHM Campus, Opp. Conway Received Nov 15; Accepted Dec Pawar and P. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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